The US Senate will pass all the nominees through. The opportunity to oppose these extremists is when they write regulations and the public comment period occurs.
This administration will cause a lot of work for everyone who cares about the country, but, it needs to be done.
Lawsuits following the institution of the regulations must follow to halt the installation of the regulations, even it eliminates it. The challenges may very well be met with obstruction by the judiciary because the extremists will all go too far and the public will be in peril.
It is important citizens participate during the comment period. I am wondering right now why I have a AARP membership.