Sunday, October 05, 2014

Do medical researchers know the exact mechanisms of this virus? What happens to lymphocytes, bone marrow and spleens?

October 5, 2014
By ABC News Radio

(WORCESTER, Mass.) — Dr. Rick Sacra, (click here) a family physician from Massachusetts who survived Ebola, was readmitted to a hospital Saturday with what doctors said appears to be an upper respiratory infection.
UMass Memorial Medical Center physicians said they believe it is likely Sacra is not suffering a relapse of Ebola, but in the interest of safety they are isolating him until they have confirmation.
Sacra, 51, underwent treatment at the Nebraska Medical Center after contracting the deadly virus while treating patients in Liberia. He was released on Sept. 26....

The treatment of transfusions of engineered antibodies worked. How do the patients receiving the transfusions fair against survivors that did not receive the treatment?

Viral hemorrhagic fevers (VHFs) (click here) refer to a group of illnesses that are caused by several distinct families of viruses. In general, the term "viral hemorrhagic fever" is used to describe a severe multisystem syndrome (multisystem in that multiple organ systems in the body are affected). Characteristically, the overall vascular system is damaged, and the body's ability to regulate itself is impaired. These symptoms are often accompanied by hemorrhage (bleeding); however, the bleeding is itself rarely life-threatening. While some types of hemorrhagic fever viruses can cause relatively mild illnesses, many of these viruses cause severe, life-threatening disease.

These symptoms Dr. Sarca is exhibiting might not be so strange for the type of fever he fought.

What I am thinking is that survivors of Ebola actually didn't impair their immune system and/or blood system because it had to build in order to stop the virus. Receiving antibodies may have inhibited the complete recovery. The body didn't have to work as hard to survive.

There are also some rather nasty respiratory microbes these days as well.

Not regarding Ebola, but, the Enterovirus D68 was only found in four of the nine children experiencing paralysis. It reminds me of Guillain-Barre syndrome. There are studies that abound about Guillian-Barre syndrome stating the cause is everything from a virus to a vaccine (which is an attenuated virus). The entire medical history of the children need to be examined. D68 is obviously hitting neurological pathways, but, perhaps in some cases without manifesting the symptoms of the four that were very ill from it. There must have been complete differentiated cell counts of all nine children. I thought it might show a pattern. A visual microscopic examination would be helpful. Sed rates may be interesting, too.

Medical investigators aren't using people, including children, as guinea pigs so much as victims that may be able to end the success of microbe vs human immune response. It is necessary to have information to better understand the human response to disease. Red blood cells are relatively stable components to any human circulatory system. There are diseases such as Sickle Cell that distort the shapes and function of the blood cells. But, human white blood cells are very plastic. They are mostly predictable, however, they are also more susceptible to rising to the challenge in ending the microbe. Visual examination would reveal any novel response.