Central nervous tissue is highly vascular, so blood
vessels should be a significant feature in any histological specimen of
CNS. Large vessels generally remain on the surface of the brain
or spinal cord, so only smaller vessels penetrate into gray and white matter.
Such small vessels may not be immediately recognizable as such. As in other regions of the body, capillaries may be quite inconspicuous due to small size. Even venules and arterioles may be small enough that the layers in their walls are not clearly visible. Blood cells may be washed out during preparation. Nevertheless, such vessels should be noticed, since they play a crucial role in brain function and pathology.
Blood vessels are generally the largest structural elements in neuropil and in white matter (i.e., even capillaries are larger in diameter than most CNS axons and dendrites). The thumbnails below link to several spinal cord specimens in which blood vessels may be observed. Blood vessels appear similar in any region of the brain.
We all know blood vessels are vital to the survival of tissue anywhere in the body. We have witnessed the "compartment syndrome' of a famous journalist in all places an airplane receive an injury that cut off the blood circulation to his lower arm. Blood circulation is vital.
If injury occurs and tau proteins released, the brain tissues microtubules can no long function to circulate vital fluids containing oxygen and cellular food.
So, I think we are getting a fairly good picture to what is occurring with concussion injuries in the NFL. The injury insults the blood circulation and the tau proteins are released from the damaged micro blood vessel and the deterioration begins.
It is understandable, isn't it? It all makes sense to me. I hope it makes sense ot others. I don't think there is a mysterious anything happening with the brain so much as understandable processes or deterioration. In that one can also understand why one player may or may not have the same symptoms as other peers.
Such small vessels may not be immediately recognizable as such. As in other regions of the body, capillaries may be quite inconspicuous due to small size. Even venules and arterioles may be small enough that the layers in their walls are not clearly visible. Blood cells may be washed out during preparation. Nevertheless, such vessels should be noticed, since they play a crucial role in brain function and pathology.
Blood vessels are generally the largest structural elements in neuropil and in white matter (i.e., even capillaries are larger in diameter than most CNS axons and dendrites). The thumbnails below link to several spinal cord specimens in which blood vessels may be observed. Blood vessels appear similar in any region of the brain.
We all know blood vessels are vital to the survival of tissue anywhere in the body. We have witnessed the "compartment syndrome' of a famous journalist in all places an airplane receive an injury that cut off the blood circulation to his lower arm. Blood circulation is vital.
If injury occurs and tau proteins released, the brain tissues microtubules can no long function to circulate vital fluids containing oxygen and cellular food.
So, I think we are getting a fairly good picture to what is occurring with concussion injuries in the NFL. The injury insults the blood circulation and the tau proteins are released from the damaged micro blood vessel and the deterioration begins.
It is understandable, isn't it? It all makes sense to me. I hope it makes sense ot others. I don't think there is a mysterious anything happening with the brain so much as understandable processes or deterioration. In that one can also understand why one player may or may not have the same symptoms as other peers.
