I was just reading a UK review of ACTT-1 trial of remdesivir.

It is having its greatest impact on lesser sick patients. Patients that are ill and on supplemental oxygen find the best result. 

Okay. So, the patients that are very sick and on ventilators are still receiving dexamethasone as their best friend in this pandemic. The remdesivir is still being administered to these patients.

Dexamethosone is proven to be a huge benefit to all patients. 

These are my initial thoughts about this review I read in the dialogue called "The CONVERSATION." 

I think patients have to be treated very early in the disease process. The earlier the infection and showing symptoms is the time to begin both these medications. Now, there is no discussion of the Regeneron REGN-Cov2 Antibody Cocktail (click here). That can be emergently approved by the FDA and perhaps it should. But, this article discusses a UK finding about remdesivir. I think it's greatest message is to administer remdesivir as early as possible for people that test positive and are having symptoms. 

The problem with that proposal is the expense and availability of remdesivir. If the financial markets want consistent and plenty of profit, they need to invest in GILEAD and in particular their product VEKLURY (the registered trademark) redesivir. PLEASE invest in the production of this medication. It is helpful in fighting this virus and no one disagrees with that fact.

The results of the ACTT-1 trial, (click here) which looked at the effectiveness of remdesivir as a treatment for COVID-19, have finally been published. So far the only drug that has been shown to reduce deaths from the disease has been dexamethasone, a steroid that suppresses the immune system through its anti-inflammatory effects. Steroids have a secondary effect on the disease – they don’t target the virus itself. Remdesivir, on the other hand, goes straight to the cause of the disease by inhibiting the virus....

...They found that patients receiving the drug improved and recovered more quickly, were less likely to progress to severe disease, were discharged from hospital sooner, and had a lower death rate of 11.4% compared with 15.2% in patients receiving “usual” treatment....

Why do I believe early administration to a person with a positive SARS-CoV-2 and showing symptoms is when this medication needs to start? It is a viral load. I haven't seen the study directly, but, I am confident there are blood tests in that trial and there are viral load recorded. THERE IS AN OPTIMAL VIRAL LOAD that remdesivir can vanquish with the body's help and dexamethasone as a companion treatment.

It only makes sense. Remdesivir attacks the virus. There is a maximum does that the human body can tolerate. So, the higher the viral load will demand MORE DAYS to be effective opposed to a lower viral load and the dosage tolerable will have a greater impact.

Remdesivir works against this virus. It is vital to determine it's most effective dosage and it's optimal time in the infection to begin and sustain administration to remove this virus from a person's body. There has to be an independent decision about children, but, it is vital it is determined.

Children need their own testing tool because at this point the adult testing places them into treatment at the point where they have a heavy viral load in a small person. Children must be tested at a point where the virus is at an early point in it's invasion of the child's body. The adult tests are ineffective and only identity a viral load too late in children.

If remdesivir is to help children maximally, early detection is vital and early administration begun early in their infection to avoid the inflammatory disease. That inflammatory disease in children causes tissue damage they will have for the rest of their lives. We need to concentrate on a vital child test that works for all ages even infancy to find when they are infected and begin treatment in measured amounts of medication to end the virus attack on them.

Observations I have made about families with young children is that the adults are oblivious to the danger their infants can face. The parents are walking with strollers. The adults and older children are wearing masks, but, the infant in the stroller is completely exposed. The family focus must be a great concern and more education carried out to end the neglect of the babies and toddlers to their danger from this virus.

I congratulate all those so very diligent in finding treatments and vaccines. They are unsung heroes alongside of the front line workers. They are also the best friends to the front line workers to end the virus as soon as possible, optomize the patients ability to fight back and provide faster recovery to a negative testing status after treatment. 

Best to all and thank you so very, very much for keeping both oars in the water.

She was in tuned to the country and ready to act on the first day. She should have been president.

Implicit Bias was a concern of Hillary Clinton. Now, look at what we have, White Supremacist/Nationalists standing down and standing by. We would not have minority deaths or protests in our streets.

The American people need to identify expertise rather than popularity.

New Zealand has 22 deaths. Just 22. They had one set back and is considered recovered from it.

October 7, 2020
By Livia Albeck-Ripka

The first time New Zealand (click here) thought it had eliminated the coronavirus from its isolated shores, a mysterious outbreak in its largest city shattered any sense of victory over a tenacious foe.

Now, after a second round of strict lockdown, the country believes — if a bit more tentatively this time — that it has effectively stamped out the virus once again.

On Wednesday, New Zealand moved to lift the last of its restrictions in Auckland after 10 days with no new cases linked to a cluster that first surfaced in August. The government will now allow unrestricted gatherings, and trips on public transit without social distancing or masks, in the city of 1.6 million people.

Prime Minister Jacinda Ardern, who is facing re-election next week, called the reopening a validation of the country’s “go hard, go early” response. The strategy is aimed at eradicating the virus with a swift science-based policy, one that trades weeks of lockdown and sacrifice for an emergence to full economic activity....

They call it "Go hard and go early." It is the only reasonable response to SARS-CoV-2. By lenient policy of the Trump White House, it is dooming the USA to chronic illness and premature death, poor economics due to chronic illness and losses in qualified workers, and isolation in a world interested in eliminating the virus.

New Zealand closes it's borders and shut down its interior. As the outbreaks are contained within a short period of time by days or the longest, weeks, the country reopens.

It isn't a great global environment for the financial markets. The Federal Reserve has the greatest input with the markets. There was never a guarantee to any private endeavor that elation at profits will be showered over them forever. The fact the USA has been grossly mismanaged by Trump and the Republican Governors there is absolutely no clear vision for the future, EXCEPT, there is a need to end the virus permanently.

15 August 2020

By Eleanor Ainge Roy

...“Go hard and go early” (click here) was New Zealand’s motto, and combined with strict border controls and high compliance with lockdown measures from “the team of 5 million” it seemed to have worked. Until now.

“I was gutted obviously. We had reached 100 days so it does feel like a kick in the teeth,” said Dr Siousxie Wiles, a British microbiologist and science communicator who lives in Auckland, a city of 1.5 million.

“But we know that with people coming in there is the chance this would happen.”

Wiles praised the government’s resurgence strategy as “absolutely spot-on” and said it had shown an impressive ability to adapt and move swiftly through alert levels.

“They have been very fast and very transparent. The speed which they moved people up the alert levels really frightened people, but this is the way to do it. What we will see now is: how quickly can you stamp out an outbreak?”...

The IMF is assessing the response by each country and offering its assessment about the coming year. The views of the future definitely rely on the effectiveness of "COVID-19 strategies." Weeks of closure is a blip, not a terminal response to any economy.

13 October 2020

...The IMF (click here) estimated Tuesday that the global economy will shrink 4.4% for 2020. That would be the worst annual plunge since the Great Depression of the 1930s. By comparison, the international economy contracted by a far smaller 0.1% after the devastating 2008 financial crisis....

Her agenda is well protected.

Coney - Barrett didn't come to answer questions, only avoid them.

She is an academician first and a judge second. She is still employed at Notre Dame as a professor of law.

There was a second plot against Northam. The defendents are talking to mitigate their charges.

October 13, 2020
By Tresa Baldas and Paul Egan

Detroit - The suspects accused of plotting (click here) to kidnap Michigan Gov. Gretchen Whitmer also talked about "taking" Virginia Gov. Ralph Northam out of anger about the leader's lockdown order during the COVID-19 pandemic, an FBI agent testified Tuesday.

Special FBI agent Richard Trask disclosed this detail during a preliminary examination in U.S. District Court in Grand Rapids, Michigan, where five suspects have bond hearings scheduled for Tuesday to determine if they should be released or remain jailed pending the outcomes of their cases.

Prior to the bond hearings, Trask outlined the FBI's case against the men, alleging they are part of a larger group of self-titled militia members from multiple states who met online earlier this year and discussed attacking government officials....

Ted Cruz is making empty arguments.

The practice of medicine has become sophisticated to either induce or perform a caesarian section on a viable fetus. Viable fetuses have been whisked to the Neonatal Intensive Care Units out of abortion clinics already.

Democrats are on record as being opposed to Dark Money.

Joe Biden is receiving donations from normally Republican donors is because the Republican Party has been completely irresponsible to our democracy and left Trump in office in the face of danger to the country.

The Second Amendment would need an amendment process whereby two-thirds of the Senate and US House and the people in order to remove the Second Amendment. The same thing is true about selling the US Post Office to a private company. Trump is not allowed to sell the USPS as Snyder did with assets of Michigan cities. It isn't easy to undo the amendments so all the drama is unnecessary.

Not one question to the judge yet. He is making a stump speech to keep Texas from turning Blue.

The Brennan Center can explain "Citizens United" better than Ted Cruz.

December 12, 2019
By Tim Lau

January 21, 2020 (click here) will mark a decade since the Supreme Court’s ruling in Citizens United v. Federal Election Commission, a controversial decision that reversed century-old campaign finance restrictions and enabled corporations and other outside groups to spend unlimited funds on elections.

While wealthy donors, corporations, and special interest groups have long had an outsized influence in elections, that sway has dramatically expanded since the Citizens United decision, with negative repercussions for American democracy and the fight against political corruption....

Disclosures

Coney-Barrett only yesterday disclosed her relationships with activists and their organizations who oppose abortion. That has to effect her standing as a current judge in the seventh appellant court. She never completely disclosed. She lied under oath.

She obviously has a hidden agenda. She never stopped affiliating with those groups even after she took a place on the 7th Appellant Court. She intends to deceive about her positions to conceal any objectionable idea.

She took the chance of disclosing this time because it is the end of the road for her. The Supreme Court is her goal to spread her particular politics no different than Thomas or Alito.

She also see herself being confirmed by a corrupt Republican Senate. She has no fear. Being covert is no longer a "safe" strategy. Being covert would be a danger to her position in the Supreme Court. It would be such a shame to have come all this way and not achieve her tightly held and silent goals.

Her covert status in her plans has nothing to do with religion. She lied to protect her plans for whatever reason she has been covert. Making plans to undermine stare decisis and due process is no small plan.

Due Process is what sets the USA apart as a government that enforces fairness and balance to it's Rule of Law.

I might add, the extremist right plans to execute women that have abortions. What a hideous reality and completely in opposition to each other morally. Prolife’s anti-abortion stand is in complete moral opposition to the death sentence.