In reflecting on marijuana, it is a very powerful plant. It has chemical structures that effect the human nervous system. Additionally, from reading this article, CBD is eliminated through the liver. If the liver is damaged it can effect the degree to which other medications also eliminated through the liver carry out their therapeutic purposes.
One of the reasons all this mess started is because marijuana is not legalized as a smoked recreational substance. Marijuana needs to be legalized as a recreational substance for adults and a lot of this will stop.
Growers need to be certified, licensed and subject to regular inspections.
From NIH:
...THC Plasma concentrations (click here) decrease rapidly after the end of smoking due to rapid distribution into tissues and metabolism in the liver. THC is highly lipophilic and initially taken up by tissues that are highly perfused, such as the lung, heart, brain, and liver. Tracer doses of radioactive THC documented the large volume of distribution of THC and its slow elimination from body stores....
November 27, 2019
By Nicoletta Lanese
Yesterday (Nov. 26), the U.S. Food and Drug Administration (FDA) (click here) issued warning letters to 15 companies that sell CBD products because the products violate federal law. The agency also issued an update to consumers about the popular products, and stressed that there is limited evidence for their safety....
...These companies have broken federal law by marketing the unproven health benefits of their CBD products, mixing the drug into food, or advertising CBD as a dietary supplement, the FDA announced yesterday. What's more, these companies may have placed their customers at unknown risk, the FDA said.
"We remain concerned that some people wrongly think that the myriad of CBD products on the market, many of which are illegal, have been evaluated by the FDA and determined to be safe, or that trying CBD 'can’t hurt,'" Dr. Amy Abernethy, the FDA's principal deputy commissioner, said in a statement....
...For instance, when scientists first tested the safety of the approved CBD epilepsy drug, they noted that CBD could inflict damage to the liver. If taken without medical supervision, the damage could prove more extensive, the FDA said in a consumer update on cannabis-derived compounds. Several studies indicate that CBD may alter how the body breaks down other drugs, either increasing or decreasing their potency. In addition, studies in animals suggest the compound may impede the function of testes and sperm, deplete testosterone levels and impair male sexual behavior.
Some reports have uncovered contaminants "such as pesticides and heavy metals" in CBD products, the FDA said. Other studies highlight the potential side effects of taking the compound, including sleep disruption, diarrhea, abdominal pain and mood changes. And questions still linger about how repeated CBD exposure might affect someone over time.
Moreover, the compound may trigger unknown effects in vulnerable populations, including pregnant people and children. Some of the companies called out today specifically market products "for infants and children," who may not metabolize and excrete the drug as adults do, the agency noted....
