Organophosphate (OP) compounds (click here) are a diverse group of chemicals used in both domestic and industrial settings. Examples of organophosphates include the following:
Insecticides – Malathion, parathion, diazinon, fenthion, dichlorvos, chlorpyrifos, ethion
Nerve gases – Soman, sarin, tabun, VX
Ophthalmic agents – Echothiophate, isoflurophate
Antihelmintics – Trichlorfon
Herbicides – Tribufos (DEF), merphos
Industrial chemical (plasticizer) – Tricresyl phosphate
Thus, organophosphate toxicity can result from household or occupational exposure, military or terrorist action, or iatrogenic mishap. Exposure to organophosphates is also possible via intentional or unintentional contamination of food sources. Although no clinical effects of chronic, low-level organophosphate exposure from a food source have been shown, advancements in risk assessment and preparedness are ongoing....
This is simply an article to add perspective to the unknown and known nature of cholinesterase and concern by medical science investigators.
"Treatment and Management of Disorders of the Neuromuscular Junction" (click here)
By Shin J. Oh, MD
Neuromuscular Disorders: Treatment and Management, 2001
Oximes
Cholinesterase reactivators (oximes) should be theoretically effective as an antidote for OP poisoning. Oximes work by removal of the phosphoryl group from the inhibited AChE enzyme, resulting in enzyme reactivation. When given before aging (permanent inhibition of the cholinesterase enzyme), oximes are generally regarded as effective treatments in reversing nicotinic signs. Pralidoxime (PAM) is the most commonly used oxime worldwide. However, a meta-analysis of various trials did not conclusively prove the efficacy of PAM....
