National Research Council (US) Committee on Methods of Producing Monoclonal Antibodies.
Washington (DC): National Academies Press (US); 1999.
About 25,000 mAb (click here) are listed in Linscott’s Directory (1998–99). Most are produced in small quantities (less than 0.1 g) for bench-related research purposes (de Geus and Hendriksen 1998b). However, some have become commercially successful and so require a scale of production different from that usually experienced in research facilities. Commercial interests consider production scales of 0.1–10 g as small, 10–100 g as medium, and over 100 g as large. Commercial-scale production is generally performed to produce mAb for three purposes: diagnosis, therapy, and research on and development of new therapeutic agents....
